Teri Melese

Academic Biography

T. Melese

Contact Information

UCSD Research Depaartment

Email: tmelese@ucsd.edu

Teri Melese

Associate Professor Emerita in Medicine and, the Rady School of Management

Teri Melese, PhD, is an Associate Professor Emerita in Medicine and, the Rady School of Management. Teri also held the position of Assistant Vice Chancellor, Industry Research Alliances in the Office of Research Affairs at University of California, San Diego. She is both a practitioner and a thought leader in academic/industry partnering strategy and has authored several articles in this area in high-profile journals. Her interests are in how to craft the most impactful academic /industry partnerships and how such partnerships can drive and enhance both the public benefit mission of the university and internal research collaborations. Previously, she has run an independent research laboratory at Columbia University and was a founding member of a venture-backed startup company, Iconix Biosciences. She has four patents to her name and holds an A.B., a Ph.D. and was an American Cancer Senior Postdoctoral Fellow and was a NSF Young Presidential Investigator. Teri is available at tmelese@ucsd.edu.

Peer Reviewed Publications and Reviews

Fraser, Heather, Marshall, Anthony and Melese,Teri : Reinventing Life Sciences: How emerging ecosystems fuel innovation, 2015

Fraser, Heather, Marshall, Anthony and Melese,Teri : The Evolution of Life Science Ecosystems: Five effective innovation approaches for academia, 2015

Fraser, Heather, Marshall, Anthony and Melese,Teri : New and Necessary in Life Sciences: Six innovation strategies from industry leaders, 2015

Fraser, Heather, Marshall, Anthony and Melese, Teri: Innovating Life Sciences; Lessons from Success,  Innovation secrets from the world’s most successful life sciences companies 2015

Katherine A. Rauen, Anuradha Banerjee, W. Robert Bishop, Jennifer O. Lauchle, Frank Mccormick, Martin Mcmahon, Teri Melese, Pamela N. Munster, Sorena Nadaf, Roger J. Packer, Judith Sebolt-Leopold, And David H. Viskochil  Costello and Cardio-Facio-Cutaneous Syndromes:  Moving Toward Clinical Trials in RASopathies American  Journal of Medical Genetics Part C (Seminars in Medical Genetics): 1-11, 2011.

Lorizio, W, Rugo, H, Beattie, M., Tchu, S.,Melese,T, Melisko, M.,Wu H.B.Alan, Lawrence, J. Nikoloff, M., and Ziv, E. Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment, Genome Medicine, 3: 64, 2011

Katherine A. Rauen, Lisa Schoyer, Frank McCormick, Angela E. Lin, Judith E. Allanson,David A. Stevenson, Karen W. Gripp, Giovanni Neri, John C. Carey, Eric Legius, Marco Tartaglia,Suzanne Schubbert, Amy E. Roberts, Bruce D. Gelb, Kevin Shannon, David H. Gutmann, Martin McMahon, Carmen Guerra, James A. Fagin, Benjamin Yu, Yoko Aoki, Benjamin G. Neel, Allan Balmain, Richard R. Drake, Garry P. Nolan, Martin Zenker, Gideon Bollag, Judith Sebolt-Leopold, Jackson B. Gibbs, Alcino J. Silva, E. Elizabeth Patton, David H. Viskochil, Mark W. Kieran, Bruce R. Korf, Randi J. Hagerman, Roger J. Packer, and Teri Melese.  Proceedings From the 2009 Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back, American Journal of Medical Genetics (Part A): 1-21, 2009

Melese Teri, Lin Salima M., Chang Julia L. & Cohen Neal H.  Open innovation networks between academia and industry: an imperative for breakthrough therapies 2009 Nature Medicine, Vol. 15: 502-507.

Vottero Eduardo, Balgi Aruna, Woods Kate, Tugendreich Stuart, Melese Teri, Andersen Raymond J, Mauk A Grant, and Roberge Michel. Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast.  2006 Biotechnology Journal, Vol. 1: 282-288.

Melese T. Building and Managing Corporate Alliances in an Academic Medical Center. 2006 Research Management Review, Vol 15-1.

Tugendreich Stuart, Perkins Ed, Couto Joe, Barthmaier Peter, Sun Dongxu, Tang Shawn, Tulac Suzana, Nguyen Allen, Yeh Elaine, Mays Amy, Lila Tom, Shivak David, Prichard Mark, Andrejka Laura, Kim Raymond and Melese Teri. A Streamlined Process to Phenotypically Profile Human cDNAs in Parallel Using Yeast Cell-based Assays. 2001 Genome Research, Vol. 11: 1899-1912.

Perkins, E., Sun, D., Nguyen, A., Tulac, S., Francesco, M., Tavana, H., Nguyen, H., Tugendreich, S., Barthmaier, P., Couto, J., Yeh, E., Thode, S., Jarnagin, K., Jain, A., Morgans, D. and Melese, T. Novel inhibitors of PARP1 and PARP2 identified using a cell-based screen in Yeast. 2001 Cancer Res. Vol. 61: 4175-4183.

Yan, Catherine, Leibowitz, Noah and Melese, Teri. A role for the divergent actin gene, ACT2, in nuclear pore structure and function. 1997 EMBO J. Vol. 16: 3572-3586.

Shan, Xiaoyin, Xue, Zhixiong, Euskirchen, Ghia and Melese, Teri. Nnf1 is an essential yeast gene required for proper spindle orientation nucleolar and nuclear envelope structure and mRNA export. 1997 Journal of Cell Science Vol. 110: 1615-1624.

Xue, Zhixiong, Shan, Xiaoyin, Sinelnikov, Alex and Melese, Teri. Yeast mutants that produce a novel type of ascus containing asci instead of spores. 1996 Genetics Vol. 144: 979-989.

Shan, Xiaoyin, Xue, Zhixiong and Melese,Teri. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. 1994 Journal of Cell Biology Vol. 126: 853-862.

Xue, Zhixiong, Shan, Xiaoyin, Lapeyre, Bruno and Melese, Teri. The amino terminus of mammalian nucleolin specifically recognizes SV40 T-antigen type nuclear localization sequences. 1993 European Journal of Cell Biology Vol. 62: 13-21.

Yan, Catherine and Melese, Teri. Multiple Regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus. 1993 Journal of Cell Biology Vol. 123: 1081-1091

Lee, Wen-Ching, Zabetakis, Daniel and Melese,Teri. NSR1 is required for pre-rRNA processing and for the proper maintenance of steady state levels of ribosomal subunits. 1992 Molecular and Cellular Biology Vol. 12: 3865-3871.

Lee, Wen-Ching, Xue, Zhixiong and Melese, Teri.The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifs. 1991 Journal of Cell Biology Vol. 113: 1-12.

Lee, Wen-Ching and Melese, Teri Identification and characterization of a nuclear localization sequence-binding protein in yeast. 1989 Proc. Nat’l. Acad. Sci. USA Vol. 86: 8808-8812.

Xue Zhixiong, Melese,Teri, Stempel, Kerstin, Reedy T.J. and Boyer, Paul D. Properties of chloroplast F1 ATPase partially modified by 2 azido adenine nucleotides, including demonstration of 3 catalytic pathways. 1988 J. Biol. Chem. Vol. 263: 16880-16885

Melese, Teri, Xue, Zhixiong, Stempel, Kerstin and Boyer, Paul D. Catalytic Properties of chloroplast F1 ATPase modified at catalytic or non-catalytic sites by 2-azido adenine nucleotides. 1988 J. Biol. Chem. Vol. 263: 5833-5840.

Zhou, Jun Mei, Xue, Zhixiong, Melese, Teri and Boyer Paul D. The relationship of tightly bound ADP and ATP to control and catalysis by the chloroplast ATP synthase. 1988 Biochemistry Vol. 27: 5129-5135.

Xue, Zhixiong, Zhou, Jun Mei, Melese,Teri, Cross, Richard L. and Boyer, Paul D, Accelerated Publication Chloroplast F1 ATPase has more than three nucleotide binding sites and both catalytic and non-catalytic sites are on or close to the ß-subunit.1987 Biochemistry Vol. 26: 3749-3753

Melese, Teri and Boyer, P.D. Derivatization of the catalytic subunits of the chloroplast ATPase by 2-azido ATP and dicyclohexylcarbodiimide: Evidence for catalytically induced interchange of the subunits.1985 J. Biol. Chem. Communication Vol. 260:15398-15401

Kanpal, Rajandra P., Melese, Teri, Stroop, Steven D. and Boyer Paul D. Mitochondrial F1 ATPase will bind and cleave ATP and slowly release products after DCCD or NBD-Cl derivatization of one subunit.1985 J. Biol. Chem. Vol. 260: 5542-5547.

Melese,Teri and Rothman, Stephen S. Increased phosphate efflux from the acinar cell during protein secretion. 1983 Amer. J. Physiol. Vol. 244, Cell Section C121-C124

Melese, Teri and Rothman, Stephen S. Distribution of three hexose derivatives across the pancreatic epithelium: Paracellular shunts or cellular passage? 1983 Biochim. et. Biophysica. Acta Vol. 763: 212-219.

Melese, Teri and Rothman, Stephen S. The pancreatic epithelium is permeable to sucrose and inulin across secretory cells. 1983 Proc. Nat’l. Acad. Sci. USA Vol. 80, 4870-4874.